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gonadal ridge
In embryology, the gonadal ridge (or genital ridge) is the precursor to the gonads. The gonadal ridge initially consists mainly of mesenchyme and cells of underlying mesonephric origin. Once oogonia enter this area they attempt to associate with these somatic cells. Development proceeds and the oogonia become fully surrounded by a layer of cells (pre-granulosa cells).
The gonadal ridge appears at approximately five weeks, and gives rise to the sex cords.
==Genes associated with the genital ridge==
Genes associated with the developing gonad can be categorized into those that form the sexually indifferent gonad, those that determine whether the indifferent gonad will differentiate as male or female, and those that promote differentiation into male or female parts. Genes that form the sexually indifferent gonad are ''SF1'' and ''WT1''. Genes that determine sex are ''Sry'', ''Sox9'', and ''Dax1''. Genes driving the differentiation into male or female structures are ''SF1'', ''WT1'', and ''Wnt-4''. Sry is the only gene expressed solely in the developing gonad. The other genes have roles in development that aren’t exclusively sex-related. (Raymond 1999)
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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